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目的 制备具有靶向性的磁性Fe_3O4纳米粒新型纳米递药系统，并进行表征，探讨柠檬酸改性的可行性。方法 用高温热解法制备包裹油胺的磁性Fe_3O4纳米粒，并用柠檬酸对其进行修饰，对制得的产品通过X射线衍射仪、傅立叶变换红外光谱仪、激光粒度仪等手段进行分析表征。结果 成功制备出磁性Fe_3O4纳米粒，平均粒径为(91.24±7)nm和PDI(多分散指数)为0.223,而且Fe_3O4表面性质的改善可以用柠檬酸，包覆效果良好。结论 通过高温热解法制得的磁性四氧化三铁纳米粒适合用于构建磁靶向药物传递体系。
Abstract：Objective To prepare and characterize a novel drug delivery system of magnetic Fe_3O4 nanoparticles with targeting properties, and explore the feasibility of citric acid modification. Methods Magnetic Fe_3O4 nanoparticles coated with oleylamine were prepared by high temperature pyrolysis, and modified with citric acid.The obtained products were analyzed and characterized by means of X-ray diffractometer, Fourier transform infrared spectrometer and laser particle size analyzer.Results Successfully prepared magnetic Fe_3O4 nanoparticles with an average particle size of(91.24±7)nm and a PDI(polydispersion index) of 0.223,and the improvement of the surface properties of Fe_3O4 was coated with citric acid.Conclusion The magnetic ferric oxide nanoparticles prepared by high temperature pyrolysis are suitable for constructing magnetic targeting drug delivery system.
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基本信息:
DOI：10.16751/j.cnki.2095-4646.2022.06.0466
中图分类号:TQ138.11;TQ460.4;TB383.1
引用信息:
[1]王高强,卯明艳,余开湖.磁性四氧化三铁纳米粒的制备、表面改性及表征[J].湖北科技学院学报(医学版),2022,36(06):466-470.DOI:10.16751/j.cnki.2095-4646.2022.06.0466.
基金信息:
国家自然科学基金/配套(81571644P)
2022-06-17
2022
2023-01-12
2023
2023-01-07
1
2022-12-15
2022-12-15