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<正>芹菜素(apigenin)又称芹黄素。是一种黄酮类化合物,其化学结构为4,5,7-三羟基黄酮,分子式为C15H10O6,相对分子质量270。纯品呈浅黄色或黄色粉末,几乎不溶于水,部分溶于热酒精,溶于稀KOH溶液、二甲基亚砜(DMSO)。芹菜素作为一种分布广泛的天然植物成分,有着其重要的药理学价值。近年来对芹菜素的研究也越来越活跃,其新的药理学活性也被逐渐发掘。本文就芹
Abstract:[1]Shukla S,Fu P,Gupta S.Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer[J].Apoptosis,2014,19(5):883
[2]Singh V,Sharma V,Verma V,et al.Apigenin manipulates the ubiquitin-proteasome system to rescue estrogen receptor-βfrom degradation and induce apoptosis in prostate cancer cells[J].Eur J Nutr,2015,54(8):1255
[3]Chen JY,Chen JQ,Li ZY,et al.The apoptotic effect of apigenin on human gastric carcinoma cells through mitochondrial signal pathway[J].Tumor Biology,2014,35(8):7719
[4]Lefort EC,Blay J.The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human coloncarcinoma cells[J].Clin Exp Metastasis,2011,28(4):337
[5]刘斌,刘太香,白明,等.芹菜素增强阿司匹林对结肠癌细胞的增殖抑制作用及其机制研究[J].中国肿瘤临床,2013,40(8):436
[6]Tang AQ,Cao XC,Tian L,et al.Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3-derived sphere-forming cells[J].Mol Med Rep,2015,11(3):2221
[7]Suh YA,Jo SY,Lee HY,et al.Inhibition of IL-6/STAT3axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells[J].Int Oncol,2015,46(3):1405
[8]Chen WY,Hsieh YA,Tsai CI,et al.Protoapigenone,a natural derivative of apigenin,induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferaseπ[J].Invest New Drugs,2011,29(6):1347
[9]张伟然,张斌,刘博文,等.芹菜素诱导乳腺癌MDAMB-23细胞系非P5依赖性凋亡的研究[J].中国肿瘤临床,2013,40(3):134
[10]Seo HS,Choi HS,Kim SR,et al.Apigenin induces apoptosis via extrinsic pathway,inducing p53 and inhibiting STAT3 and NFj B signaling in HER2-overexpressing breast cancer cells[J].Mol Cell Biochem,2012,366(1-2):319
[11]杨志英,邓志刚,伍健明,等.芹菜素对胶质瘤细胞增殖抑制作用的研究[J].浙江临床医学,2012,14(6):641
[12]Chakrabarti M,Narik NL,Ray SK.Sequential h TERT knockdown and apigenin treatment inhibited invasion and proliferation and induced apoptosis in human malignant neuroblastoma SK-N-DZ and SK-N-BE2 Cells[J].J Mol Neurosci,2013,51(1):187
[13]Nakazaki E,Tsolmon S,Han J,et al.Proteomic study of granulocytic differentiation induced by apigenin 7-glucoside in human promyelocytic leukemia HL-60 cells[J].Eur J Nutr,2013,52(1):25
[14]Gonzalez-Mejia ME,Voss OH,Murnan EJ,et al.Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein-27[J].Cell Death Dis,2010,1:e64
[15]Wang J,Liu YT,Xiao L,et al.Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-k B pathway[J].Inflammation,2014,37(6):2085
[16]Patil RH,Babu RL,Naveen Kumar M,et al.Apigenin inhibits PMA-induced expression of pro-inflammatory cytokines and AP-1 factors in A549 cells[J].Mol Cell Biochem,2015,403(1-2):95
[17]Arango D,Diosa-Toro M,Rojas-Hernandez LS,et al.Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation[J].Mol Nutr Food Res,2015,59(4):763
[18]Paredes-Gonzalez X,Fuentes F,Su ZY,et al.Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse Skin epidermal JB6 P+Cells through epigenetics modifications[J].AAPS J,2014,16(4):727
[19]Huang CS,Lii CK,Lin AH,et al.Protection by chrysin,apigenin,and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1and glutamate cysteine ligase in rat primary hepatocytes[J].Arch Toxicol,2013,87(1):167
[20]张新娟,左国营,张云玲,等.芹菜素联合抗生素的抗耐甲氧西林金黄色葡萄球菌作用[J].中国医院学杂志,2012,32(10):755
[21]Qian S,Fan W,Qian P,et al.Apigenin Restricts FMDV infection and inhibits viral IRES driven translational activity[J].Viruses,2015,7(4):1613
[22]Hu J,Li Z,Xu LT,et al.Protective effect of apigenin on ischemia/reperfusion injury of the isolated rat heart[J].Cardiovasc Toxicol,2015,15(3):241
[23]王仙,于肯明.芹菜素对大鼠阿霉素性心肌损伤的影响[J].中西医结合心血管病杂志,2011,9(1):60
[24]崔英杰.芹菜素对自发性高血压大鼠心血管重塑的保护作用[J].中国药物与临床,2013,13(5):602
[25]Wang Q,Zeng P,Liu Y,et al.Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis[J].Int Immunopharmacol,2015,27(1):24
[26]Zhang F,Li F,Chen G.Neuroprotective effect of apigenin in rats after contusive spinal cord injury[J].Neurol Sci,2014,35(4):583
[27]Goto T,Hagiwara K,Shirai N,et al.Apigenin inhibits osteoblastogenesis and osteoclastogenesis and prevents bone loss in ovariectomized mice[J].Cytotechnology,2015,67(2):357
[28]汪云开,黄兆铨.芹菜素对同型半胱氨酸诱导的人脐静脉内皮细胞氧化损伤的保护作用[J].中华中医药学刊,2012,30(5):969
[29]辜学敏,吴华振,韩坚,等.芹菜素改善肥胖型2型糖尿病小鼠胰岛素抵抗的实验研究[N].国际医药卫生导报,2012,18(14):2033
[30]Wang QQ,Cheng N,Yi WB,et al.Synthesis,nitric oxide release,andα-glucosidase inhibition of nitric oxide donating apigenin and chrysin derivatives[J].Bioorg Med Chem,2014,22(5):1515
[31]金妍,徐华影,陈琛.马齿苋抗糖尿病活性成分的研究[J].中成药,2015,37(1):124
基本信息:
DOI:10.16751/j.cnki.2095-4646.2016.03.0273
中图分类号:R285.5
引用信息:
[1]郭霜,张晚霞,余薇.芹菜素药理作用的研究进展[J].湖北科技学院学报(医学版),2016,30(03):273-276.DOI:10.16751/j.cnki.2095-4646.2016.03.0273.
基金信息:
湖北省自然科学基金项目(2014CFB382); 湖北科技学院科研课题(ZX1305,BK1408)
2015-09-29
2015
2016-07-09
2016
1
2016-07-13
2016-07-13
2016-07-13