| 567 | 75 | 54 |
| 下载次数 | 被引频次 | 阅读次数 |
目的探究讨鸡血藤醇提取物对小鼠炎性痛的镇痛作用。方法制备鸡血藤的醇提取物。以生理盐水和血竭素高氯酸盐为对照组,鸡血藤醇提取物为实验组,采用热板法、醋酸扭体法、醋酸抬腿法以及CFA(完全弗氏佐剂)法建立小鼠疼痛模型,研究鸡血藤醇提取物的镇痛作用。结果鸡血藤醇提取物能够减少醋酸诱发的小鼠扭体反应次数、抬腿反应次数,减轻CFA诱发的小鼠足趾容积肿胀程度,升高小鼠的热痛阈。结论鸡血藤醇提取物对小鼠炎症性疼痛有明显的镇痛作用。
Abstract：Objective To study the inhibitory effect of caulis spatholobi extract on inflammatory pain in mice. Methods The alcohol extract of caulis spatholobi was prepared.The normal saline and draconis perchlorate were used as the control group,and the ethanol extract of caulis spatholobi was used as the experimental group.The pain models of mice established by hot plate method,acetic acid writhing method,acetic acid leg lifting method and CFA(complete Freund's adjuvant) method were used to explore the effect of alcohol extract of caulis spatholobi on inflammatory pain.Results The alcohol extract of caulis spatholobi could significantly reduce the number of body twisting induced by acetic acid,the number of leg lifts,and the volume of toe volume swelling induced by CFA,and significantly elevate the heat pain threshold in mice.Conclusion Alcohol extract of caulis spatholobi has obviously analgesic effect on inflammatory pain in mice.
[1]谢婵娟,许湘华,欧美军,等.慢性疼痛患者心理灵活性的研究进展[J].中国全科医学,2019,22(8):973
[2]陈井国.什么是炎症?炎症发生的原因是什么?[J].生物学通报,2001,36(2):44
[3]国家药典委员会.中国药典[M].北京:中国医药科技出版社,2015:194
[4]刘屏,王东晓,陈桂芸.儿茶素对骨髓细胞周期及造血生长因子基因表达的作用[J].药学学报,2004,39(6):424
[5]梁宁,温海成,陆惠燕.壮药鸡血藤提取物毒性作用及体外抗肿瘤作用的实验研究[J].中国民族医药杂志,2010,9(9):3
[6]唐旗羚,曹颖男,徐娟娟,等.鸡血藤组方提取物的抗肿瘤作用及其机制初探[J].中国医药指南,2018,16(15):34
[7]曾凡力,程悦,陈建萍.鸡血藤醇提物体外抗病毒活性研究[J].中药新药与临床药理,2011,1:16
[8]郭金鹏,庞佶,王新为.鸡血藤水提物体外抗肠道病毒作用研究[J].实用预防医学,2007,14(2):349
[9]史晓普,刘洋,王景迪.鸡血藤乙醇提取物对四氯化碳所致小鼠急性肝损伤的保护作用[J].延边大学医学学报,2015,38(2):99
[10]文东旭.龙血竭的研究进展[J].中草药,2001,32(11):1053
[11]张小郁.草血竭镇痛抗炎作用的研究[J].中药药理与临床,2001,17(2):19
[12]KIM J,KIM J,MIN K S,et al.VPL-DBS on neuropathic pain rat model is effective in mechanical allodynia than cold allodynia[J].Neurol Sci,2012,33(6):1265
[13]毛晓丽.望江南对小鼠慢性炎症痛镇痛作用的研究[J].大家健康旬刊,2016,10(5):138
[14]符影,程悦,陈建萍.鸡血藤化学成分及药理作用研究进展[J].中草药,2011,42(6):1229
[15]刘静,王晓静,戴忠,等.鸡血藤研究进展[J].中国药事,2019,33(2):188
[16]周志刚,张斯.疼痛医学的新进展[J].河南外科学杂志,2003,9(6):46
[17]张夏辉,蒋世云,傅凤鸣.鸡血藤中黄酮类化合物提取工艺的研究[J].化学分析计量,2013,22(1):92
基本信息:
DOI：10.16751/j.cnki.2095-4646.2019.06.0461
中图分类号:R285.5
引用信息:
[1]吴磊,颜曼,邱春玉.鸡血藤醇提物对小鼠炎性痛的影响[J].湖北科技学院学报(医学版),2019,33(06):461-464.DOI:10.16751/j.cnki.2095-4646.2019.06.0461.
2020-01-07
2020-01-07
2020-01-07