湖北科技学院学报（医学版）

目的：观察山药的抗糖尿病作用效力。方法：采用四氧嘧啶制作糖尿病小鼠模型，并以优降糖作阳性对照。连续21天用不同剂量的山药灌胃治疗，比较各组生化指标的差异。结果：①与对照组比，剂量在6．00g／Kg·d(-1)以上的山药各组的血糖和血脂含量较低（P＜0．001或P＜0．05），而肝糖元和心肌糖元含量较高（P＜0．001或P＜0．01）。②与优降糖组比，剂量在6．00g／Kg·d(-1)以上的山药各组的血糖、血脂和心肌糖元含量较高（P＜0．001或P＜0．01），而肝糖元含量较低（P＜0．01）。结论：山药有一定的抗糖尿病作用，但效力显著弱于优降糖，且需剂量大。

Objective To observe the antidiabetic effect of Dioscoren Opposita Thunb (DOT). Methods The diabetic mice model was established by intra-abdominal injection of alloxan,then the living mice were divided into five groups three of them were respectively treated with different dose of DOT; one group was treated with glibenclamide as standard control; and another one was non-treated as experimental control. After a periode of 21-day treatment, the relevant biochemical indexes were determined. Results ①Comparing with the experimental control group, in DOT group (dosage>6. 00g/kg·d(-1) ) the content of glucose and tri-acylglycerol in plasma were lower (P< 0. 001 or P< 0. 05 ), but glycogen in liver and myocardium tissues was higher (P< 0.001 or P<0. 01 ). ②Comparing with glibenclamide group, in DOT group (dosage > 6. 00g/kg·d(-1) ) the contents of glucose and tri-acylglycerol in plasma were higher (P < 0. 001 ), and the glycogen in liver tissues was lower (P< 0. 001 ) but in myocardium was higher (P< 0. 01 ). Conclusion DOT has a certain anti-diabetic effect when its dosage is massive, and the effect is much lower than that of glibenclamide.