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非酒精性脂肪肝病(NAFLD)是最常见的肝病之一，如不及时诊治，可逐渐发展为肝纤维化、肝硬化甚至肝癌。因此，阐明NAFLD的诱发机制，有助于从根本上了解NAFLD,为治疗NAFLD提供理论依据。本文简述了NAFLD的诱发机制以及中药的治疗研究现状，认为中药的多成分虽然能够多靶点作用于NAFLD,改善NAFLD,但中药及其有效成分发挥作用的具体机制尚未完全清楚，仍需进一步研究，以期为NAFLD的治疗提供新思路和研究方向，并为今后该领域的中药深入研究提供参考。
Abstract：Non-alcoholic fatty liver disease(NAFLD) is one of the most common liver diseases, which can gradually develop into liver fibrosis, cirrhosis and even liver cancer if not diagnosed and treated in time. Therefore, elucidating the triggering mechanism of NAFLD will help to understand NAFLD fundamentally and provide a theoretical basis for the treatment of NAFLD. This paper briefly describes the triggering mechanism of NAFLD and the current status of therapeutic research on TCM,and concludes that although the multi-components of TCM are capable of multi-targeting NAFLD and improving NAFLD,the specific mechanism by which TCM and its active ingredients play a role has not yet been fully clarified, and further research is still needed. This review is in order to provide the new ideas and research directions for the treatment of NAFLD,and provide reference for the in-depth research of TCM in this field in the future.
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基本信息:
DOI：10.16751/j.cnki.2095-4646.2024.01.088
中图分类号:R259
引用信息:
[1]黄兴琼,高满军,李炎坤,等.非酒精性脂肪肝的诱发机制及中药治疗研究进展[J].湖北科技学院学报(医学版),2024,38(01):88-92+2.DOI:10.16751/j.cnki.2095-4646.2024.01.088.
基金信息:
糖尿病心脑血管病变湖北省重点实验室开放基金项目(2022TNB07); 湖北科技学院博士科研启动基金(BK202336)