湖北科技学院学报（医学版）

目的：观察山药对糖尿病小鼠组织丙二醛（ ＭＤＡ） 含量的影响。方法：采用四氧嘧啶制作糖尿病小鼠模型，并以优降糖作阳性对照，连续２１ 天用不同剂量山药灌胃治疗，比较各组心脏、肝脏、肾脏和胰脏过氧化脂质的终末代谢产物ＭＤＡ 含量。结果：①对照组四器官ＭＤＡ显著高于正常组（Ｐ＜ ０ ．０１ 或Ｐ＜ ０ ．００１） ；②剂量在６ ．００ｇ／ｋｇ·ｄ－ １ 以上山药各治疗组四器官ＭＤＡ显著低于对照组（Ｐ＜ ０ ．０５ 或Ｐ＜ ０．００１） ；③与优降糖组比，除肝脏ＭＤＡ 较高外（Ｐ＜ ０．００１） ，中、大剂量山药组心、胰、肾组织ＭＤＡ 较低（Ｐ＜ ０ ．０５ 或Ｐ＜ ０ ．００１） 。结论：山药能明显降低糖尿病小鼠组织内过氧化脂质含量，尤其对心组织作用最强，其次为胰、肾和肝组织，而优降糖对胰组织过氧化脂质无明显影响。

Objective To observe the effect of Dioscoren Opposita Thunb(DOT) on MDA content in tissues of alloxan induced diabetic mice.Methods The diabetic mice model was established by intra abdominal injection of alloxan.After the DOT treatment (in contrast with glibenclamide) for a period of 21 days,determine and compare the contents of malonyldiadehyde(MDA) in heart,liver,pancreas and kidney tissues of the mice of all groups.Results ①Comparing with the normal group,in diabetic control group the contents of MDA in four kinds of tissue were obviously higher(P<0.0.1 or P<0.001).②Comparing with the diabetic control group,in DOT group(dosage>6.00g/kg·d -1 ) the contents of MDA in four kinds of tissue were obviously lower(P<0.05 or P<0.01).③Comparing with glibenclamide group,in DOT group (dosage>6.00g/kg·d -1 ) the contents of MDA in heart,pancreas and kidney tissues were lower(P<0.01 or P<0.001),but in liver tissues were higher (P<0.001).Conclusion DOT is able to significantly decrease the contents of lipoperoxide in tissues of diabetic mice,and this effect is most obviously showed on heart tissue,then is on pancresa,kidney and liver tissue sequentially.The above effect of glibenclamide on pancreas tissue is not obvious.